{"id":3105,"date":"2025-05-22T15:10:32","date_gmt":"2025-05-22T12:10:32","guid":{"rendered":"https:\/\/www.doktorikool.ee\/?post_type=tribe_events&#038;p=3105"},"modified":"2025-06-09T09:38:21","modified_gmt":"2025-06-09T06:38:21","slug":"professor-tomi-rantamagi-kulalisseminar-naerugaas-kui-vahend-kiirete-antidepressantsete-mojude-uurimiseks","status":"publish","type":"tribe_events","link":"http:\/\/www.doktorikool.ee\/en\/uritused\/professor-tomi-rantamagi-kulalisseminar-naerugaas-kui-vahend-kiirete-antidepressantsete-mojude-uurimiseks\/","title":{"rendered":"Guest seminar by Professor Tomi Rantam\u00e4ki: \u201eLaughing Gas as a Tool to Uncover Rapid Antidepressant Effects\u201c"},"content":{"rendered":"<div  class=\"tribe-events-schedule tribe-clearfix\" >\n\t<p class=\"tribe-events-schedule__datetime\">\n\t\t<span class=\"tribe-events-schedule__date tribe-events-schedule__date--start\">\n\t\t\t10\/06\/2025\t\t<\/span>\n\n\t\t\t\t\t<span class=\"tribe-events-schedule__separator tribe-events-schedule__separator--date\">\n\t\t\t\t \t\t\t<\/span>\n\t\t\t<span class=\"tribe-events-schedule__time tribe-events-schedule__time--start\">\n\t\t\t\t10:00\t\t\t<\/span>\n\t\t\n\t\t\t\t\t\t\t\t\t<span class=\"tribe-events-schedule__separator tribe-events-schedule__separator--time\">\n\t\t\t\t\t &#8211; \t\t\t\t<\/span>\n\t\t\t\n\t\t\t\t\t\t\t<span class=\"tribe-events-schedule__time tribe-events-schedule__time--end\">\n\t\t\t\t\t10:45\t\t\t\t<\/span>\n\t\t\t\n\t\t\t\t\t\t<\/p>\n<\/div>\n\n\n\n<p class=\"wp-block-paragraph translation-block\"><strong>At Biomedicum of Tartu University<\/strong> (Ravila 19, Tartu), <strong>room 0088<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>The seminar is in English<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The seminar will focus on the neurobiological mechanisms of rapid-acting antidepressants and the ENCORE-D hypothesis linking cortical excitation, sleep-like states, and TrkB signaling.<\/p>\n\n\n\n<p class=\"wp-block-paragraph translation-block\">The speaker is <strong>Professor Tomi Rantam\u00e4ki<\/strong>, PhD, Principal Investigator, Laboratory of Neurotherapeutics, Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy and sleepWell Research Program, Faculty of Medicine, University of Helsinki, Finland<\/p>\n\n\n\n<div class=\"custom-css-block\"><style>#aab_accordion_48cc9e05_0 {  }<\/style><\/div><div class=\"wp-block-aab-accordion-block aab__accordion_container  accessibilityOn\" style=\"margin-top:0px;margin-bottom:15px;border:1px solid #bcb6b638\" id=\"aab_accordion_48cc9e05_0\" role=\"button\" aria-expanded=\"false\" tabindex=\"0\"><div class=\"aab__accordion_head aab_right_icon\" style=\"border-top:none;border-right:none;border-bottom:none;border-left:none\"><div class=\"aab__accordion_heading aab_right_icon aab_right_link\"><div class=\"head_content_wrapper\"><div class=\"title_wrapper\"><h5 class=\"aab__accordion_title\" style=\"margin:0\"><strong>Summary<\/strong><\/h5><\/div><p class=\"aab__accordion_subheading\" placeholder=\"\" style=\"margin:5px 0 0 0\"><\/p><\/div><\/div><div class=\"aab__accordion_icon\" style=\"border:\"><span class=\"aab__icon dashicons dashicons-plus-alt2\" style=\"font-size:\"><\/span><\/div><\/div><div class=\"aab__accordion_body\" role=\"region\" style=\"display:none\"><div class=\"aab__accordion_component\">\n<p class=\"wp-block-paragraph\">Dr. Rantam\u00e4ki and his team investigates neurobiological mechanisms of rapid-acting antidepressants. Latest results from his lab suggest that rapid-acting antidepressant drugs, such as ketamine and nitrous oxide, share the ability to acutely excite cortical networks. This \u201cpharmacological challenge\u201d evokes homeostatic emergence of slow EEG activity (SWA) and other characteristic features of deep sleep such as reduced brain energy expenditure and drop in the body temperature. Importantly, key molecular signaling mechanisms, most notably activation of TrkB neurotrophin receptors, become specifically regulated in the cortex after the acute pharmacological effects of the drugs dissipate and body temperature drops. Remarkably, maintaining normothermia abolishes drug-induced TrkB activation and ameliorates antidepressant-like behavior responses in rodents. Dr. Rantam\u00e4ki will present his recently formulated hypothesis called ENCORE-D (encoding, consolidation and renormalization in depression) that explains rapid and sustained antidepressant drug effects beyond the principles of conventional receptor pharmacology. Neurobiology of sleep is at the very center of this hypothesis.<\/p>\n<\/div><\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Estonian Doctoral School for Medical and Health Sciences, Veterinary Medicine.<\/p>\n\n\n\t<div  class=\"tribe-block tribe-block__events-link\" >\n\t\t<div class=\"tribe-events tribe-common\">\n\t\t\t<div class=\"tribe-events-c-subscribe-dropdown__container\">\n\t\t\t\t<div class=\"tribe-events-c-subscribe-dropdown\">\n\t\t\t\t\t<div class=\"tribe-common-c-btn-border tribe-events-c-subscribe-dropdown__button\">\n\t\t\t\t\t\t<svg\n\t class=\"tribe-common-c-svgicon tribe-common-c-svgicon--cal-export tribe-events-c-subscribe-dropdown__export-icon\" \taria-hidden=\"true\"\n\tviewbox=\"0 0 23 17\"\n\txmlns=\"http:\/\/www.w3.org\/2000\/svg\"\n>\n\t<path fill-rule=\"evenodd\" clip-rule=\"evenodd\" d=\"M.128.896V16.13c0 .211.145.383.323.383h15.354c.179 0 .323-.172.323-.383V.896c0-.212-.144-.383-.323-.383H.451C.273.513.128.684.128.896Zm16 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class=\"tribe-common-c-svgicon__svg-fill\"\/>\n<\/svg>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div id=\"tribe-events-subscribe-dropdown-content\" class=\"tribe-events-c-subscribe-dropdown__content\">\n\t\t\t\t\t\t<ul class=\"tribe-events-c-subscribe-dropdown__list\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<li class=\"tribe-events-c-subscribe-dropdown__list-item 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ENCORE-D h\u00fcpoteesile, mis seob ajukoore erutust, unelaadseid seisundeid ja TrkB signalisatsiooni. Seminar [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"template":"","meta":{"inline_featured_image":false,"_EventAllDay":false,"_EventTimezone":"Europe\/Tallinn","_EventStartDate":"2025-06-10 10:00:00","_EventEndDate":"2025-06-10 10:45:00","_EventStartDateUTC":"2025-06-10 07:00:00","_EventEndDateUTC":"2025-06-10 07:45:00","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"$","_EventCurrencyCode":"USD","_EventCurrencyPosition":"prefix","_EventDateTimeSeparator":" ","_EventTimeRangeSeparator":" - ","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false,"_tribe_events_status":"","_tribe_events_status_reason":"","footnotes":""},"tags":[],"tribe_events_cat":[],"class_list":["post-3105","tribe_events","type-tribe_events","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/www.doktorikool.ee\/en\/wp-json\/wp\/v2\/tribe_events\/3105","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.doktorikool.ee\/en\/wp-json\/wp\/v2\/tribe_events"}],"about":[{"href":"http:\/\/www.doktorikool.ee\/en\/wp-json\/wp\/v2\/types\/tribe_events"}],"author":[{"embeddable":true,"href":"http:\/\/www.doktorikool.ee\/en\/wp-json\/wp\/v2\/users\/1"}],"version-history":[{"count":2,"href":"http:\/\/www.doktorikool.ee\/en\/wp-json\/wp\/v2\/tribe_events\/3105\/revisions"}],"predecessor-version":[{"id":3131,"href":"http:\/\/www.doktorikool.ee\/en\/wp-json\/wp\/v2\/tribe_events\/3105\/revisions\/3131"}],"wp:attachment":[{"href":"http:\/\/www.doktorikool.ee\/en\/wp-json\/wp\/v2\/media?parent=3105"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.doktorikool.ee\/en\/wp-json\/wp\/v2\/tags?post=3105"},{"taxonomy":"tribe_events_cat","embeddable":true,"href":"http:\/\/www.doktorikool.ee\/en\/wp-json\/wp\/v2\/tribe_events_cat?post=3105"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}