{"id":3036,"date":"2025-04-30T15:17:45","date_gmt":"2025-04-30T12:17:45","guid":{"rendered":"https:\/\/www.doktorikool.ee\/?post_type=tribe_events&#038;p=3036"},"modified":"2025-04-30T15:17:46","modified_gmt":"2025-04-30T12:17:46","slug":"seminar-gracile-syndrome-a-fetal-onset-mitochondrial-progeria","status":"publish","type":"tribe_events","link":"https:\/\/www.doktorikool.ee\/en\/uritused\/seminar-gracile-syndrome-a-fetal-onset-mitochondrial-progeria\/","title":{"rendered":"Seminar &#8220;GRACILE Syndrome \u2013 A Fetal-Onset Mitochondrial Progeria&#8221;"},"content":{"rendered":"<div  class=\"tribe-events-schedule tribe-clearfix\" >\n\t<p class=\"tribe-events-schedule__datetime\">\n\t\t<span class=\"tribe-events-schedule__date tribe-events-schedule__date--start\">\n\t\t\t06\/05\/2025\t\t<\/span>\n\n\t\t\t\t\t<span class=\"tribe-events-schedule__separator tribe-events-schedule__separator--date\">\n\t\t\t\t \t\t\t<\/span>\n\t\t\t<span class=\"tribe-events-schedule__time tribe-events-schedule__time--start\">\n\t\t\t\t11:00\t\t\t<\/span>\n\t\t\n\t\t\t\t\t\t\t\t\t<span class=\"tribe-events-schedule__separator tribe-events-schedule__separator--time\">\n\t\t\t\t\t &#8211; \t\t\t\t<\/span>\n\t\t\t\n\t\t\t\t\t\t\t<span class=\"tribe-events-schedule__time tribe-events-schedule__time--end\">\n\t\t\t\t\t11:45\t\t\t\t<\/span>\n\t\t\t\n\t\t\t\t\t\t<\/p>\n<\/div>\n\n\n\n<p><strong>Biomedicum, Ravila 19, Room 0093<\/strong><\/p>\n\n\n\n<p class=\"translation-block\">Dr. Jukka Kallij\u00e4rvi\u2019s group investigates mitochondrial respiratory chain complex III (CIII) deficiencies, particularly GRACILE syndrome, a severe multiorgan metabolic disease in newborn infants first described in Finland. Using a patient mutation knock-in mouse model, his lab explores pharmacological, dietary, and gene therapy interventions to uncover novel treatments and understand the pathogenesis of this condition. This seminar will provide an overview of his work on GRACILE Syndrome.<\/p>\n\n\n\n<p><strong>Dr Jukka Petri Kallij\u00e4rvi<\/strong>, Folkh\u00e4lsan Research Center and Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki<\/p>\n\n\n\n<p>Contact: Allen Kaasik, <a href=\"mailto:allen.kaasik@ut.ee\"><span style=\"text-decoration: underline;\">allen.kaasik@ut.ee<\/span><\/a><\/p>\n\n\n\n<p>Estonian Doctoral School for Medical and Health Sciences, Veterinary Medicine.<\/p>\n\n\n\t<div  class=\"tribe-block tribe-block__events-link\" >\n\t\t<div class=\"tribe-events tribe-common\">\n\t\t\t<div class=\"tribe-events-c-subscribe-dropdown__container\">\n\t\t\t\t<div class=\"tribe-events-c-subscribe-dropdown\">\n\t\t\t\t\t<div class=\"tribe-common-c-btn-border tribe-events-c-subscribe-dropdown__button\">\n\t\t\t\t\t\t<svg\n\t class=\"tribe-common-c-svgicon tribe-common-c-svgicon--cal-export tribe-events-c-subscribe-dropdown__export-icon\" \taria-hidden=\"true\"\n\tviewbox=\"0 0 23 17\"\n\txmlns=\"http:\/\/www.w3.org\/2000\/svg\"\n>\n\t<path fill-rule=\"evenodd\" clip-rule=\"evenodd\" d=\"M.128.896V16.13c0 .211.145.383.323.383h15.354c.179 0 .323-.172.323-.383V.896c0-.212-.144-.383-.323-.383H.451C.273.513.128.684.128.896Zm16 6.742h-.901V4.679H1.009v10.729h14.218v-3.336h.901V7.638ZM1.01 1.614h14.218v2.058H1.009V1.614Z\" \/>\n\t<path d=\"M20.5 9.846H8.312M18.524 6.953l2.89 2.909-2.855 2.855\" stroke-width=\"1.2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\n<\/svg>\n\t\t\t\t\t\t<button\n\t\t\t\t\t\t\tclass=\"tribe-events-c-subscribe-dropdown__button-text\"\n\t\t\t\t\t\t\taria-expanded=\"false\"\n\t\t\t\t\t\t\taria-controls=\"tribe-events-subscribe-dropdown-content\"\n\t\t\t\t\t\t\taria-label=\"View links to add events to your calendar\"\n\t\t\t\t\t\t>\n\t\t\t\t\t\t\tAdd to calendar\t\t\t\t\t\t<\/button>\n\t\t\t\t\t\t<svg\n\t class=\"tribe-common-c-svgicon tribe-common-c-svgicon--caret-down tribe-events-c-subscribe-dropdown__button-icon\" \taria-hidden=\"true\"\n\tviewbox=\"0 0 10 7\"\n\txmlns=\"http:\/\/www.w3.org\/2000\/svg\"\n>\n\t<path fill-rule=\"evenodd\" clip-rule=\"evenodd\" d=\"M1.008.609L5 4.6 8.992.61l.958.958L5 6.517.05 1.566l.958-.958z\" class=\"tribe-common-c-svgicon__svg-fill\"\/>\n<\/svg>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div id=\"tribe-events-subscribe-dropdown-content\" class=\"tribe-events-c-subscribe-dropdown__content\">\n\t\t\t\t\t\t<ul class=\"tribe-events-c-subscribe-dropdown__list\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<li class=\"tribe-events-c-subscribe-dropdown__list-item tribe-events-c-subscribe-dropdown__list-item--gcal\">\n\t\t\t\t\t\t\t\t\t<a\n\t\t\t\t\t\t\t\t\t\thref=\"https:\/\/www.google.com\/calendar\/event?action=TEMPLATE&#038;dates=20250506T110000\/20250506T114500&#038;text=Seminar%20%26%238220%3BGRACILE%20Syndrome%20%E2%80%93%20A%20Fetal-Onset%20Mitochondrial%20Progeria%26%238221%3B&#038;details=%3Cp%3E%3Cstrong%3ERavila+19%2C+Biomeedikum%2C+aud.+0093%3C%2Fstrong%3E%3C%2Fp%3E+%3Cp%3EDr.+Jukka+Kallij%C3%A4rvi+t%C3%B6%C3%B6r%C3%BChm+uurib+mitokondriaalse+hingamisahela+kompleksi+III+%28CIII%29+puudulikkust%2C+keskendudes+eriti+GRACILE+s%C3%BCndroomile+%E2%80%93+raskele+mitmeid+organeid+kahjustavale+metaboolsele+haigusele%2C+mis+esineb+vasts%C3%BCndinutel+ja+mida+kirjeldati+esimesena+Soomes.+Kasutades+patsiendi+mutatsiooni+%3Cem%3Eknock-in%3C%2Fem%3E+hiiremudeleid%2C+uurib+tema+labor+erinevaid+l%C3%A4henemisviise%2C+sealhulgas+farmakoloogilisi%2C+dieedi-+ja+geeniteraapia+v%C3%B5imalusi%2C+et+leida+uusi+raviv%C3%B5imalusi+ja+selgitada+haiguse+patogeneesi.+Loeng+annab+%C3%BClevaate+tema+t%C3%B6%C3%B6st+GRACILE+s%C3%BCndroomi+uurimisel.%3C%2Fp%3E+%3Cp%3E%3Cstrong%3EDr+Jukka+Petri+Kallij%C3%A4rvi%3C%2Fstrong%3E%2C+Folkh%C3%A4lsan+Research+Center+and+Stem+Cells+and+Metabolism+Research+Program%2C+Faculty+of+Medicine%2C+University+of+Helsinki%3C%2Fp%3E+%3Cp%3EKontakt%3A+Allen+Kaasik%2C+%3Ca+href%3D%22mailto%3Aallen.kaasik%40ut.ee%22%3E%3Cspan+style%3D%22text-decoration%3A+underline%3B%22%3Eallen.kaasik%40ut.ee%3C%2Fspan%3E%3C%2Fa%3E%3C%2Fp%3E+%3Cp%3EEesti+doktorikooli+arst%3C%2Fp%3E+%28View+Full+event+Description+Here%3A+https%3A%2F%2Fwww.doktorikool.ee%2Fen%2Furitused%2Fseminar-gracile-syndrome-a-fetal-onset-mitochondrial-progeria%2F%29&#038;trp=false&#038;ctz=Europe\/Tallinn&#038;sprop=website:https:\/\/www.doktorikool.ee\/en\"\n\t\t\t\t\t\t\t\t\t\tclass=\"tribe-events-c-subscribe-dropdown__list-item-link\"\n\t\t\t\t\t\t\t\t\t\ttarget=\"_blank\"\n\t\t\t\t\t\t\t\t\t\trel=\"noopener noreferrer nofollow noindex\"\n\t\t\t\t\t\t\t\t\t>\n\t\t\t\t\t\t\t\t\t\tGoogle Calendar\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<li class=\"tribe-events-c-subscribe-dropdown__list-item tribe-events-c-subscribe-dropdown__list-item--ical\">\n\t\t\t\t\t\t\t\t\t<a\n\t\t\t\t\t\t\t\t\t\thref=\"\"\n\t\t\t\t\t\t\t\t\t\tclass=\"tribe-events-c-subscribe-dropdown__list-item-link\"\n\t\t\t\t\t\t\t\t\t\ttarget=\"_blank\"\n\t\t\t\t\t\t\t\t\t\trel=\"noopener noreferrer nofollow noindex\"\n\t\t\t\t\t\t\t\t\t>\n\t\t\t\t\t\t\t\t\t\tiCalendar\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<li class=\"tribe-events-c-subscribe-dropdown__list-item tribe-events-c-subscribe-dropdown__list-item--outlook-365\">\n\t\t\t\t\t\t\t\t\t<a\n\t\t\t\t\t\t\t\t\t\thref=\"\"\n\t\t\t\t\t\t\t\t\t\tclass=\"tribe-events-c-subscribe-dropdown__list-item-link\"\n\t\t\t\t\t\t\t\t\t\ttarget=\"_blank\"\n\t\t\t\t\t\t\t\t\t\trel=\"noopener noreferrer nofollow noindex\"\n\t\t\t\t\t\t\t\t\t>\n\t\t\t\t\t\t\t\t\t\tOutlook 365\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<li class=\"tribe-events-c-subscribe-dropdown__list-item tribe-events-c-subscribe-dropdown__list-item--outlook-live\">\n\t\t\t\t\t\t\t\t\t<a\n\t\t\t\t\t\t\t\t\t\thref=\"\"\n\t\t\t\t\t\t\t\t\t\tclass=\"tribe-events-c-subscribe-dropdown__list-item-link\"\n\t\t\t\t\t\t\t\t\t\ttarget=\"_blank\"\n\t\t\t\t\t\t\t\t\t\trel=\"noopener noreferrer nofollow noindex\"\n\t\t\t\t\t\t\t\t\t>\n\t\t\t\t\t\t\t\t\t\tOutlook Live\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Ravila 19, Biomeedikum, aud. 0093 Dr. Jukka Kallij\u00e4rvi t\u00f6\u00f6r\u00fchm uurib mitokondriaalse hingamisahela kompleksi III (CIII) puudulikkust, keskendudes eriti GRACILE s\u00fcndroomile \u2013 raskele mitmeid organeid kahjustavale metaboolsele haigusele, mis esineb vasts\u00fcndinutel [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"template":"","meta":{"inline_featured_image":false,"_EventAllDay":false,"_EventTimezone":"Europe\/Tallinn","_EventStartDate":"2025-05-06 11:00:00","_EventEndDate":"2025-05-06 11:45:00","_EventStartDateUTC":"2025-05-06 08:00:00","_EventEndDateUTC":"2025-05-06 08:45:00","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"$","_EventCurrencyCode":"USD","_EventCurrencyPosition":"prefix","_EventDateTimeSeparator":" ","_EventTimeRangeSeparator":" - ","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false,"_tribe_events_status":"","_tribe_events_status_reason":"","footnotes":""},"tags":[],"tribe_events_cat":[],"class_list":["post-3036","tribe_events","type-tribe_events","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.doktorikool.ee\/en\/wp-json\/wp\/v2\/tribe_events\/3036","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.doktorikool.ee\/en\/wp-json\/wp\/v2\/tribe_events"}],"about":[{"href":"https:\/\/www.doktorikool.ee\/en\/wp-json\/wp\/v2\/types\/tribe_events"}],"author":[{"embeddable":true,"href":"https:\/\/www.doktorikool.ee\/en\/wp-json\/wp\/v2\/users\/1"}],"version-history":[{"count":2,"href":"https:\/\/www.doktorikool.ee\/en\/wp-json\/wp\/v2\/tribe_events\/3036\/revisions"}],"predecessor-version":[{"id":3038,"href":"https:\/\/www.doktorikool.ee\/en\/wp-json\/wp\/v2\/tribe_events\/3036\/revisions\/3038"}],"wp:attachment":[{"href":"https:\/\/www.doktorikool.ee\/en\/wp-json\/wp\/v2\/media?parent=3036"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.doktorikool.ee\/en\/wp-json\/wp\/v2\/tags?post=3036"},{"taxonomy":"tribe_events_cat","embeddable":true,"href":"https:\/\/www.doktorikool.ee\/en\/wp-json\/wp\/v2\/tribe_events_cat?post=3036"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}