Lecture and Seminar in Reproductive Genetics “Multiomic Discovery and Functional Characterisation of Human Variants Implicated in Premature Ovarian Insufficiency”

📍 Institute of Biomedicine and Translational Medicine, University of Tartu, Biomedicum, Ravila 19, 50411 Tartu, lecture halls BM-0140 and BM-0141

The event will be held in English.

Target group

The event is intended for doctoral researchers and supervisors from the Estonian Doctoral School for Medical and Health Sciences, Veterinary Medicine.

General information

Premature ovarian insufficiency (POI) is a leading form of female infertility affecting up to 4% of women under the age of 40. We have studied a diverse cohort of over 200 girls and women with idiopathic POI using whole-exome sequencing, identifying a cause in more than 15% of cases.

The functional implications of novel POI candidate genes and genetic variants have been characterised using various approaches, including multiomic analysis of patient cells, modelling in Drosophila, zebrafish or mice, and in vitro functional assays. Importantly, we have shown that genomic sequencing can alter and improve patient management and outcomes, enabling early intervention for associated comorbidities.

Facilitator

Elena Jane TuckerMurdoch Children’s Research Institute, Melbourne, Australia;

Department of Paediatrics, University of Melbourne, Melbourne, Australia.

Registration

➤  Register HERE. The registration is open until December 2, 2026..

Everyone interested is welcome to attend.

Contact

For further information, please contact Prof Maris Laan (maris.laan@ut.ee.

Estonian Doctoral School for Medical and Health Sciences, Veterinary Medicine.